Based on the r groups of the original and substituted amino acids, explain why receptor x changed shape

(the column on the right side has numbers 1-4 as well)

from left column to the right marching definition column:
1=2
2=4
3=1
4=3

Multiple or is there any more info

After spending all that time on the research then by all means modify the hypothesis or aim by reporting such. for example the findings did not bring forth what was expected but brought about different yet interesting findings worth exploring so the hypothesis is changed to reflect this new findings.

i may be way off but.